¶ Endoluten
¶ At a Glance
| Feature | Specification |
|---|---|
| Type | Natural Peptide Bioregulator (Cytomax) |
| Source | Bovine Pineal Gland Extract |
| Primary Target | Pineal Gland (Epigenetic Regulation) |
| Key Benefits | Circadian alignment, mortality risk reduction (inferred from Epithalamin), melatonin restoration |
| Typical Dose | 10–20 mg (1–2 capsules) daily |
| Cycle Length | 30 days, repeated every 6 months |
¶ Protocol: How to Use
Endoluten is typically used in cyclic "courses" rather than continuously. The goal is to "retrain" the pineal gland rather than permanently substitute its function.
¶ Standard "Khavinson" Protocol
- Dosage: 1 capsule (10 mg) or 2 capsules (20 mg) per day.
- Timing: Morning, before food (15–30 minutes).
- Duration: 30 days.
- Frequency: Repeat the course every 6 months.
¶ Intensive Protocol (Therapeutic)
Used in Russian clinical settings for significant pathology or advanced age:
- Dosage: 2 capsules daily.
- Duration: 30 days.
- Frequency: Repeat every 3–4 months.
¶ The Context: Natural vs. Synthetic
Understanding the difference between Endoluten, Epithalamin, and Epitalon is critical for navigating this class of compounds.
| Compound | Type | Delivery | Description |
|---|---|---|---|
| Epithalamin | Natural | Injection | The original drug used in the 15+ year Khavinson studies. A complex mix of peptides extracted from the pineal gland. |
| Endoluten | Natural | Oral | The dietary supplement version of Epithalamin. Contains the same peptide complex but formulated for oral absorption (Cytomax). |
| Epitalon | Synthetic | Injection / Spray | A single tetrapeptide (Ala-Glu-Asp-Gly) identified as the active "short chain" component of the natural extract. |
¶ Why Choose Endoluten?
- Broader Spectrum: As a natural extract, Endoluten contains a complex of peptides, not just the single tetrapeptide found in Epitalon. Proponents argue this offers a more holistic "entourage effect" on the pineal gland.
- Oral Bioavailability: Unlike many peptides that degrade in the stomach, Cytomaxes (natural bioregulators) are naturally protected and have documented oral bioavailability.
- Slower, Sustained Action: Natural bioregulators are often described as acting more slowly but with longer-lasting "after-effects" compared to the rapid onset/offset of synthetic short peptides.
¶ Mechanism of Action
Endoluten operates via peptide regulation of gene expression (epigenetics).
- Nuclear Translocation: The short chain peptides in Endoluten penetrate the cell membrane and enter the nucleus of pinealocytes (pineal gland cells).
- DNA Binding: They bind to specific promoter regions of DNA.
- Protein Synthesis: This binding unlocks silenced genes, triggering the synthesis of regulatory proteins and hormones (specifically melatonin) that may have declined due to aging.
- Telomere Elongation: Like Epitalon, pineal peptides have been shown to activate telomerase and elongate telomeres in somatic cells, potentially resetting the "Hayflick limit."
¶ The Evidence: The 15-Year Russian Studies
The primary claim to fame for Endoluten rests on the massive longitudinal studies conducted by Professor Vladimir Khavinson and the St. Petersburg Institute of Bioregulation and Gerontology.
¶ The Kiev Study (1992–2007)
A 15-year randomized controlled trial involved elderly patients (mean age 75+ at start) to assess the impact of pineal and thymus peptides on mortality.
- Participants: Elderly individuals with cardiovascular pathology.
- Intervention: Courses of Epithalamin (pineal) and Thymalin (thymus) twice a year.
- Results:
- Mortality Reduction: The group receiving the peptide combination showed a 40–50% reduction in mortality compared to the control group over the observation period.
- Functional Metrics: Improved immune function, bone density, and cardiovascular resilience.
- Melatonin: Restored melatonin secretion rhythms to levels comparable with young healthy individuals.
¶ The "Siberian" Study
Another large-scale observation involved Gazprom workers working in shifts (high circadian stress). Use of pineal bioregulators resulted in significantly reduced sickness rates and improved adaptation to shift work.
¶ Animal Data
In experiments with mice and rats, administration of pineal peptides increased maximum lifespan by 20–40% and inhibited the development of spontaneous tumors.
¶ Safety and Side Effects
Endoluten is derived from natural animal tissue (bovine).
- Toxicity: No toxic effects were observed in acute or chronic toxicity studies.
- Side Effects: No adverse side effects have been reported in over 40 years of clinical application in Russia.
- Contraindications:
- Pregnancy/Lactation: Not studied; avoid.
- Autoimmune Disease: Because it stimulates the immune system (via the pineal-thymus axis), those with autoimmune conditions should proceed with caution and medical supervision.